Hepatitis C, The METAVIR System

table 4. The METAVIR System

Algorithm for Evaluation of Histological Activity^*
Piecemeal Necrosis	+	Lobular Necrosis	=	Histological Activity Score

0 (none)		0 (none or mild)		0 (none)
0		1 (moderate)		1 (mild)
0		2 (severe)		2 (moderate)
1 (mild)		0, 1		1
1		2		2
2 (moderate)		0, 1		2
2		2		3 (severe)
3 (severe)		0, 1, 2		3

Fibrosis Scoring
Score	Description

0	No fibrosis
1	Stellate enlargement of portal tract but without septa formation
2	Enlargement of portal tract with rare septa formation
3	Numerous septa without cirrhosis
4	Cirrhosis

^* Modified and reprinted with permission.⁴ Modified and reprinted with permission.³