Daklinza (daclatasvir)

When is Daklinza contraindicated?

UPDATE: Bristol Myers Squibb discontinued Daklinza effective June 2019.

The following chart provides information regarding potentially significant drug interactions with Daklinza (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Daklinza and recommendations for alterations in dose or regimen please visit www.Daklinza.com.)

Drug Class	Specific Drugs Within Class Contraindicated with Daklinza
Strong CYP3A Inhibitors	Atazanavir/ritonavir Clarithromycin Indinavir Itraconazole Ketoconazole Nefazodone Nelfinavir Posaconazole Saquinavir Telithromycin Voricanazole
Moderate CYP3A Inhibitors	Atazanavir Ciprofloxacin Darunavir/ritonavir Diltiazem Erythromycin Fluconazole Fosamprenavir Verapamil
Moderate CYP3A Inducers	Bosentan Dexamethasone Efavirenz Etravirine Modafinil Nafcillin Rifapentine
Anticoagulants	Dabigatran Etexilate Mesylate
Cardiovascular Agents	Amiodarone Digoxin
Lipid Lower Agents	Atorvastatin Fluvastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin

While the following drugs were evaluated in clinical trials, when used individually with Daklinza they had no clinically significant interactions:

cyclosporine
escitalopram
ethinyl estradiol/norgestimate
methadone
midazolam
tacrolimus
tenofovir

Last Updated: June 2019

What is the dosage for Daklinza? What type of adverse reactions were reported when taking Daklinza?

References

FDA Approved Daklinza (Daclatasvir) for the Treatment of Patients with Chronic Hepatitis C Genotype 3. http://news.bms.com/press-release/fda-approves-daklinza-daclatasvir-treatment-patients-chronic-hepatitis-c-genotype-3, Bristol-Myers Squibb Company. Retrieved July 27, 2015.

Financial Help Info for Daklinza (daclatasvir) . http://www.daklinza.bmscustomerconnect.com/support, Bristol-Myers Squibb Company. Retrieved July 27, 2015.

Highlights of Prescribing Information - DAKLINZA. http://packageinserts.bms.com/pi/pi_daklinza.pdf, Bristol-Myers Squibb Company. Retrieved July 27, 2015.

Patient Support Connect. http://www.patientsupportconnect.bmscustomerconnect.com/, Bristol-Myers Squibb Company. Retrieved July 27, 2015.