Epclusa (sofosbuvir and velpatasvir)

When is Epclusa contraindicated?

Epclusa and ribavirin combination regimen is contraindicated in those patients for whom ribavirin is contraindicated.

The following chart provides information regarding potentially significant drug interactions with Epclusa (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Epclusa and recommendations for alterations in dose or regimen please view the Full Prescribing Information.)

 

Drug Class	Specific Drugs Within Class Contraindicated with Harvoni®
Acid Reducing Agents	Antacids (e.g. aluminum and magnesium hydroxide) H2-receptor antagonists (e.g. famotidine) Proton-pump inhibitors (e.g. omeprazole)
Antiarrhythmics	Amiodarone Digoxin
Anticancers	Topotecan
Anticonvulsants	Carbamazepine Phenytoin Phenobarbital Oxcarbazepine
Antimycobacterials	Rifabutin Rifampin Rifapentine
HIV Antiretrovirals	Efavirenz Regimens containing tenofovir DF Tipranavir/ritonavir
Herbal Supplements	St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors	Rosuvastatin Atorvastatin

 

Based on drug interaction studies conducted with either Epclusa or the components of Epclusa, the following had no clinically significant interactions:

With Epclusa:

• atazanavir/ritonavir
• cyclosporine
• darunavir/ritonavir
• dolutegravir
• elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
• emtricitabine
• raltegravir
• rilpivirine

With Sofosbuvir:

• ethinyl estradiol/norgestimate
• methadone
• tacrolimus

With Velpatasvir:

• ethinyl estradiol/norgestimate
• ketoconazole
• pravastatin

 

Last Updated: June 2016