Harvoni® (ledipasvir and sofosbuvir) and Hepatitis C
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When is Harvoni® contraindicated?
You should not take Harvoni® if you also take other medicines that contain sofosbuvir. The following chart provides information regarding potentially significant drug interactions with Harvoni® (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Harvoni® and recommendations for alterations in dose or regimen please visit www.Gilead.com.)
| Drug Class | Specific Drugs Within Class Contraindicated with Harvoni® |
|---|---|
| Acid Reducing Agents | Antacids (e.g. aluminum and magnesium hydroxide) H2-receptor antagonists (e.g. famotidine) Proton-pump inhibitors (e.g. omeprazole) |
| Antiarrhythmics | Amiodarone Digoxin |
| Anticonvulsants | Carbamazepine Phenytoin Phenobarbital Oxcarbazepine |
| Antimycobacterials | Rifabutin Rifampin Rifapentine |
| HIV Antiretrovirals | Efavirenz Emtricitabine Tenofovir disoproxil Fumarate (DF) Regimens containing tenofovir DF and an HIV protease inhibitor/ritonavir Elvitegravir Cobicistat Emtricitabine Tenofovir DF Tipranavir/ritonavir |
| HCV Products | Simeprevir |
| Herbal Supplements | St. Johns’ wort (Hypericum perforatum) |
| HMG-CoA Reductase Inhibitors | Rosuvastatin |
While the following drugs were evaluated in clinical trials, when used individually with Harvoni® they had no clinically significant interactions:
- abacavir
- atazanavir/ritonavir
- cyclosporine
- darunavir/ritonavir
- efavirenz
- emtricitabine
- lamivudine
- methadone
- oral contraceptives
- pravastatin
- raltegravir
- rilpivirine
- tacrolimus
- tenofovir disoproxil fumarate
- verapamil
Last Updated: May 2015
"FDA Drug Safety Communication: FDA Warns of Serious Slowing of the Heart Rate When Antiarrhythmic Drug Amiodarone is Used with Hepatitis C Treatments Containing Sofosbuvir (Harvoni) or Sovaldi in Combination with Another Direct Acting Antiviral Drug." U.S. Food and Drug Administration, http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm. Retrieved April 10, 2015.
"Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf. Retrieved April 10, 2015.
"Harvoni® Coupon and Savings." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.
"Patient Information: Harvoni®." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_patient_pi.pdf. Retrieved April 13, 2015.
"Support Path Harvoni® and Sovaldi® Tablets Treatment Support." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.
