Hepatitis C,table 3, Hepatitis C Virus RNA Profiles in Chronically Infected Individuals: Do They Relate to Disease Activity?

Hepatitis C Virus RNA Profiles in Chronically Infected Individuals: Do They Relate to Disease Activity?

table 3. Maximum Changes of HCV RNA (Log genomes/mL) Observed in Serum During Follow-up in HCV-Infected Patients

	Monthly Sampling			Yearly Sampling
	No. of Cases	HCV-RNA Change (mean ± SD)	HCV-RNA Change (range)	No. of Cases	HCV-RNA Change (mean ± SD)	HCV-RNA Change (range)

ALT profile
Normal ALT	28	0.7 ± 0.3^*	0.2-1.4	10	0.8 ± 0.7	0.2-2.2
Elevated ALT	26	1.3 ± 0.7	0.3-3.1	12	1.0 ± 0.5	0.5-1.7
Genotype
Genotype 1	38	1.0 ± 0.5	0.2-2.2	7	1.0 ± 0.6	0.4-1.9
Genotype 2	14	1.1 ± 0.8	0.3-3.0	15	0.7 ± 0.5	0.2-1.8
Genotype 3	2	2.4 ± 1.1	1.6-3.1	0
Liver histology
Minimal changes	2	0.3 ± 0.24	0.2-0.4	1	0.2	0.2
Mild CH	18	1.3 ± 0.8	0.3-2.2	7	1.3 ± 0.7	0.4-2.2
Moderate CH	16	1.2 + 0.9	0.3-3.1	4	1.2 + 0.5	0.7-1.8
Severe CH	1	1.6	1.6	0

Abbreviation: CH = chronic hepatitis. ^* vs P = .004.