Hepatitis C, table 3, Neurovisual Impairment: A Frequent Complication of Alpha-Interferon Treatment in Chronic Viral Hepatitis

table 3

Neurovisual Impairment: A Frequent Complication of Alpha-Interferon Treatment in Chronic Viral Hepatitis

table 3. Effect of Interferon Treatment on Neurovisual Parameters of Eyes With Baseline Normal or Abnormal P100 Latencies of Visual Evoked Responses

	Baseline P100 Latency		P Value
	Normal^*(45 patients, 74 eyes)	Abnormal(24 patients, 32 eyes)	P Value

A. Before treatment
P100 latency (ms)	117.1 ± 5.7^§§	136.0 ± 8.1#	<.0001
P100 amplitude (µV)	7.07 ± 0.80#	6.85 ± 0.80#	NS
Electroretinogram (µV)	53.1 ± 5.2#	51.8 ± 7.2#	NS
Visual acuity§	9.1 ± 1.6##	7.9 ± 2.4#	.0035
Visual sensitivity (db)	25.1 ± 1.0^**	24.2 ± 1.5^***	.0120
B. End of treatment
P100 latency (ms)	122.3 ± 10.5^§§	136.2 ± 12.8#	<.0001
P100 amplitude (µV)	8.09 ± 8.22#	6.51 ± 1.30#	NS
Electroretinogram (µV)	53.7 ± 5.4#	52.8 ± 7.5#	NS
Visual acuity^,^§	8.9 ± 1.8##	7.5 ± 2.4	.0021
Visual sensitivity (db)	24.1 ± 1.7^**	22.3 ± 3.5^***	.0201

Abbreviation: NS, not significant. ^* VER <127 ms. VER 127 ms. Mean ± SD. ^§ Snellen score (in 10ths). ^§§ P = .0002 (paired and group comparisons). #P = NS. ##P = .021 (paired and group comparisons). ^ P < .001 (paired and group comparisons). P = .051 (paired comparisons). ^* P = .032 (paired comparisons).