Table 1 of the Frequency and Nature of the Variant Syndromes of Autoimmune Liver Disease

Frequency and Nature of the Variant Syndromes of Autoimmune Liver Disease

table 1. Modified Scoring System for the Diagnosis of Autoimmune Hepatitis

Category	Factor	Score	Category	Factor	Score

Sex	Female	+2	Alcohol	<25 g/d >40 g/d	0 2
Alk Phos:AST ratio	3 <3	2 +2	Immune disease	Patient or relative	+1
-Globulin or IgG levels above normal	>2.0 1.5-2.0 1.0-1.5 <1.0	+3 +2 +1 0	Histological features	Interface and acinar hepatitis with bridging Interface hepatitis Rosettes Plasma cells Biliary changes Other features	+3 +2 +1 +1 1 3
ANA, SMA, or anti-LKM1 titers	>1:80 1:80 1:40 <1:40	+3 +2 +1 0
AMA	Positive	2	Blood transfusion or drugs	Yes No	2 +1
Viral markers	HBsAg	3
	IgM anti-HAV	3
	HCV RNA	3	Pretreatment score
	Other viruses	3	Definite diagnosis		>15
	Anti-HCV	2	Probable diagnosis		10-15
	All negative	+3	Nondiagnostic		<10
HLA	DR3 or DR4	+1

Abbreviations: Alk Phos:AST ratio, ratio of serum elevations above reference value of alkaline phosphatase and aspartate transaminase; IgG, serum immunoglobulin G level; HBsAg, hepatitis B surface antigen; IgM anti-HAV, immunoglobulin M antibodies to hepatitis A virus.