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table 4. Results of Corticosteroid Therapy
|
|
| Treatment Results |
AIH + PBC (n = 12) |
AIH + PSC (n = 9) |
Autoimmune Cholangitis (n = 6) |
Definite AIH (n = 86) |
|
| Remission |
9 (75)§, |
2 (22) ,¶¶ |
0 (0) ,§ |
55 (64),¶¶ |
| Relapse |
9/9 (100) |
2/2 (100) |
0 (0) |
41/55 (74) |
| Sustained remission |
0/9 (0) |
0/2 (0) |
0 (0) |
14/55 (25) |
| Treatment failure |
0 (0) |
3 (33) |
1 (17) |
9 (10) |
Incomplete response.gif) |
2 (17) |
4 (44)** |
0 (0) |
10 (12)** |
| Liver-related death or liver transplantation |
1 (8) |
3 (33) |
2 (33) |
7 (8) |
| Poor result¶¶¶ |
2 (17) |
7 (78)*,,## |
1 (17)## |
19 (22)* |
| Developed cirrhosis |
0/8 (0)§§§,*** |
2/3 (67)§§§ |
0 (0) |
18/43 (42)*** |
| Prednisone alone |
8 (67) |
4 (44) |
5 (83)¶ |
25 (29)¶, |
| Prednisone and azathioprine |
4 (33) |
5 (56) |
1 (17)# |
61 (71)#, |
| Duration of treatment (mo) |
47 ± 16 |
28 ± 14 |
3 ± 1 |
24 ± 4 |
| Duration of follow-up (mo) |
114 ± 22 |
62 ± 38 |
3 ± 1,§§ |
94 ± 10§§ |
|
NOTE. Numbers in parentheses are percentages.
Abbreviation: AIH, autoimmune hepatitis.
Significantly different from each other at levels of *P = .001,  ,.gif) P = .003, §,P = .009, ¶,#P = .01, ** ,,,§§P = .02, ,¶¶P = .03, ##,*** ,P = .04, and ,§§§P = .05.
Incomplete response connotes the absence of a treatment end point after at least 6 months of therapy. Patients treated for shorter durations were not included.
¶¶¶ Poor result includes treatment failure and incomplete response. Death from hepatic failure and/or liver transplantation was not included as a poor result unless it occurred during immediate therapy and was categorized as a treatment failure. |
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