Hepatitis C, Relationship of the Genomic Complexity of Hepatitis C Virus With Liver Disease Severity and Response to Interferon in Patients With Chronic HCV Genotype 1b Infection | Hepatitis Central

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Relationship of the Genomic Complexity of Hepatitis C Virus With Liver Disease Severity and Response to Interferon in Patients With Chronic HCV Genotype 1b Infection

table 2. Basal Features and Complexity of the HVR1, as Determined by SSCP Analysis, in Patients With Genotype 1b HCV Chronic Infection According to the Response to a Course of Interferon Therapy

	Sustained Response (n = 12)	Transient Response (n = 41)	No Response (n = 69)

Age (years)	41.1 ± 13.0	46.4 ± 11.7	48.8 ± 11.4
Sex (M/F)	7/5	22/19	44/25
Source of infection
Blood transfusion	4 (33.3%)	11 (26.8%)	22 (31.9%)
I.V. drug abuse	3 (25%)	2 (4.9%)	4 (5.8%)
Unknown	5 (41.7%)	28 (68.3%)	43 (62.3%)
AST (IU/L)	87.8 ± 60.8	80.0 ± 52.5	109.1 ± 69.3
ALT (IU/L)	190.6 ± 138.1	142.6 ± 85.8	166.5 ± 114.6
HCV-RNA (copies × 10³/mL)	25 ± 35^*	346 ± 388	415 ± 506
Number of SSCP bands	7.5 ± 3.9	8.3 ± 2.9	8.2 ± 3.6
High complexity of quasispecies	4 (33.3%)	16 (39%)	26 (37.6%)
Low complexity of quasispecies	8 (66.7%)	25 (61%)	43 (62.4%)

NOTE. Quantitative data are expressed as means ± SD. Numbers in parenthesis represent percentages. Complexity of quasispecies was defined as low (8 bands or less) or high (more than 8 bands), according to the median value of the number of bands in the SSCP analysis. ^* Significantly different (P = .04) from transient responders and nonresponders by ANOVA.

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