Hepatitis C, Early Hepatocellular Carcinoma as an Entity With a High Rate of Surgical Cure, Current Information On Hepatitis C & treatments for the medical professional and patient.

Early Hepatocellular Carcinoma as an Entity With a High Rate of
Surgical Cure

table 2.Pathological Characteristics of HCC in 67 Patients

Characteristic	No. of Patients (%)		P
Characteristic	Early HCC Group (n = 15)	Overt HCC Group (n = 52)	P

Gross typing
Type-1	0	23 (44)
Type-2	0	8 (15)
Type-3	0	21 (41)
Type-early	15 (100)	0
Glisson’s triad present^*	15 (100)	3 (6)	<.001
Edmondson’s grading			<.001
Grade-1	15 (100)	0
Grade-2	0	42 (81)
Grade-3	0	10 (19)
Capsular formation	0	36 (69)	<.001
Regional cancer spread	1 (7)	22 (42)	.01
Vascular invasion	1 (7)	15 (29)
Intrahepatic metastasis^§	0	11 (21)
Underlying liver disease			.72
Chronic hepatitis	2 (13)	11 (21)
Cirrhosis	13 (87)	41 (79)
Dysplastic nodules or foci	7 (47)	18 (35)	.55

^* Presence of Glisson’s triad within the tumor was assessed macroscopically and later confirmed microscopically. The tumors in these patients contained discrete foci of overt HCC (type-1 and grade-2) in a grade-1 background with Glisson’s triad, and appeared as “nodule-in-nodule” lesions. Of them, tumors in four patients had both invasion and metastasis. ^§ Tumors were considered metastatic if they presented as smaller lesions around a main tumor and exhibited similar histological characteristics, or if they grew from portal vein tumor thrombi.1