Evaluation of Assays for Antibody to Hepatitis E Virus by a Serum Panel
table 1. Characteristics of 12 Tests to Detect Antibody to HEV Evaluated by the Serum Panel |
|
Laboratory |
Test |
Format |
Target HEV Protein |
Expression
|
ORF(s) |
System |
HEV Strain |
|
1 |
1 |
EIA |
Recombinant |
2 |
Insect cells |
Pakistan |
2 |
2 |
EIA |
Recombinant |
2 |
Insect cells |
Burma |
3 |
3 |
Western
blot |
Recombinant |
2 |
Insect cells |
Burma |
4 |
4 |
Western
blot |
Recombinant |
2, 3 |
E. coli |
China |
2 |
5 |
EIA |
Recombinant |
2 |
E. coli |
Burma |
5 |
6 |
EIA |
Recombinant |
2, 3 |
E. coli |
Burma, Mexico |
6 |
7 |
EIA |
Recombinant* |
2, 3 |
E. coli |
Burma, Mexico |
7 |
8 |
EIA |
Recombinant |
2, 3 |
E. coli |
Burma, Mexico |
8 |
9 |
EIA |
Synthetic peptides |
3 |
|
Burma |
3 |
10 |
EIA |
Synthetic peptides |
2 |
|
Burma |
9 |
11 |
EIA |
Synthetic peptides |
3 |
|
Burma, Mexico |
10 |
12 |
EIA |
Synthetic peptides |
2, 3 |
|
Burma, Mexico |
|
* Artificial mosaic protein consisting of a series of short linear antigenic epitopes. |
|
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Copyright © 1998 by the American Association for the Study of Liver Diseases.