Evaluation of Assays for Antibody to Hepatitis E Virus by a Serum Panel

table 2. Detection of Antibody to HEV in Known-Positive and Known-Negative Sera by 12 Different Tests

Test	Anti-HEV Reactive (n)
	Positive Sera^*		Negative Sera (n = 22)
	<6 mo (n = 9)	6 mo (n = 20)	Negative Sera (n = 22)

1	9	18	0
2	9	20	0
3	9	20	1 [6]
4	8	19	0 [1]
5	9	19	0
6	5	14 [1]	0
7	9	17	0
8	6	14	0
9	1	1	5 [2]
10	7 [1]	3 [6]	0
11	2	2	0
12	6	10	0

^* Known-positive sera included a series of convalescent human sera obtained 3 months to 13 years after acute hepatitis E and serial sera from chimpanzees inoculated with hepatitis E virus strains from various geographic regions. Results are presented for sera obtained <6 months after infection and 6 months after infection. Known-negative sera included preinoculation chimpanzee sera; sera from chimpanzees with hepatitis A virus, hepatitis B virus, or hepatitis C virus infection; and normal human sera. Numbers in brackets indicate sera with an indeterminate test result.