Evaluation of Assays for Antibody to Hepatitis E Virus by a Serum Panel

table 6. Overall Performance of 12 Tests for Antibody to HEV

Test	Overall Sensitivity^*	Limit of Detection by Endpoint Dilution	Overall Specificity

1	44 (96)	1:80	45 (98)
2	45 (98)	1:160	57 (93)
3	45 (98)	1:20	48 (79)
4	38 (83)	1:10	60 (98)
5	41 (89)	1:20	61 (100)
6	31 (67)	1:40	61 (100)
7	42 (91)	1:160	58 (95)
8	33 (72)	1:20	60 (98)
9	7 (15)	Unknown	51 (84)
10	11 (24)	1:0	61 (100)
11	11 (24)	1:5	61 (100)
12	26 (57)	1:10	60 (98)

^* No. (%) reactive among 46 positive sera (29 known positive sera and 17 blood donor sera previously reactive by at least 2 assays [tests 1, 6, and 7]). Early convalescent human serum diluted with normal human serum. No. (%) nonreactive among 61 negative sera (22 known negative sera and 39 blood donor sera previously nonreactive by at least 2 assays [tests 1, 6, and 7]).