Bilirubin
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| BilirubinSerum total bilirubin is increased in hepatocellular damage (infectious hepatitis, alcoholic and other toxic hepatopathy, neoplasms), intra- and extrahepatic biliary tract obstruction, intravascular and extravascular hemolysis, physiologic neonatal jaundice, Crigler-Najjar syndrome, Gilbert’s disease, Dubin-Johnson syndrome, and fructose intolerance.Drugs known to cause cholestasis include the following: aminosalicylic acid androgens azathioprine benzodiazepines carbamazepine carbarsone chlorpropamide propoxyphene estrogens penicillin gold Na thiomalate imipramine meprobamate methimazole nicotinic acid progestins penicillin phenothiazines oral contraceptives sulfonamides sulfones erythromycin estolate Drugs known to cause hepatocellular damage acetaminophen allopurinol aminosalicylic acid amitriptyline androgens asparaginase aspirin azathioprine carbamazepine chlorambucil chloramphenicol chlorpropamide dantrolene disulfiram estrogens ethanol ethionamide halothane ibuprofen indomethacin iron salts isoniazid MAO inhibitors mercaptopurine methotrexate methoxyflurane methyldopa mithramycin nicotinic acid nitrofurantoin oral contraceptives papaverine paramethadione penicillin phenobarbital phenazopyridine phenylbutazone phenytoin probenecid procainamide propylthiouracil pyrazinamide quinidine sulfonamides tetracyclines trimethadione valproic acid Disproportionate elevation of direct (conjugated) bilirubin is seen in Decreased serum total bilirubin is probably not of clinical significance |
