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Risk of Liver and Other Types of Cancer in Patients With Cirrhosis: A Nationwide Cohort Study in Denmark

Table  3.   Observed and Expected Numbers and SIR of Selected Cancer Sites in Different Types of Cirrhosis
Cancer Site
 Alcoholic

 Primary Biliary

 Chronic Hepatitis

 Nonspecified
Observed SIR 95% CI Observed SIR 95% CI Observed SIR 95% CI Observed SIR 95% CI
All malignant neoplasms
 877 2.2 2.1-2.4 36 1.4 1.0-1.9 187 1.7 1.4-1.9 347 2.0 1.8-2.2
Liver (primary)
 173 44.8 38.4-52.0 4 18.5 5.0-48.0 23 23.1 14.6-35.0 45 26.0 19.0-35.0
Hepatocellular carcinoma
 142 70.6 59.5-83.2 4 47.0 12.6-120.2 18 42.7 25.2-67.3 35 43.4 30.3-60.4
Cholangiocarcinoma
 17 15.3 8.9-24.5 0  ---  --- 0  ---  --- 4 7.2 1.9-18.3
Other and unspecified morphology
 14 19.0 10.4-31.8 0  ---  --- 5 23.0 7.4-53.8 6 16.6 6.0-36.0
Tobacco-related sites
 210 1.8 1.6-2.1 8 1.5 0.7-3.0 42 1.7 1.2-2.3 96 2.2 1.8-2.7
Lung
 135 2.1 1.8-2.5 1 0.4 0.0-2.0 19 1.5 0.9-2.4 52 2.3 1.7-3.0
Urinary bladder
 32 1.1 0.8-1.6 3 2.8 0.6-8.1 9 1.6 0.7-3.1 18 1.7 1.0-2.6
Kidney
 26 2.2 1.5-3.3 2 3.0 0.3-10.7 8 2.7 1.1-5.3 9 1.8 0.8-3.5
Pancreas
 17 1.6 0.9-2.6 2 2.6 0.3-9.5 6 1.8 0.7-3.9 17 3.1 1.8-5.0
Alcohol-related sites
 193 9.6 8.3-11.0 1 1.4 0.0-7.6 13 3.5 1.9-6.0 34 5.1 3.5-7.1
Buccal cavity and pharynx
 115 11.6 9.6-14.0 0  ---  --- 8 4.2 1.8-8.2 20 6.0 3.6-9.2
Esophagus
 40 9.0 6.4-12.3 1 5.4 0.1-30 1 1.1 0.0-6.1 12 7.2 3.7-12.5
Larynx
 38 6.5 4.6-9.0 0  ---  --- 4 4.7 1.3-11.9 2 1.2 0.1-4.3
Hormone-related sites*
 81 1.3 1.0-1.6 5 0.7 0.2-1.7 20 0.8 0.5-1.2 45 1.4 1.0-1.8
Breast
 44 1.6 1.2-2.2 4 0.9 0.3-2.4 11 0.7 0.4-1.3 24 1.4 0.9-2.1
Other sites, total*
 220 1.1 1.0-1.3 18 1.5 0.9-2.3 89 1.6 1.3-2.0 127 1.4 1.2-1.7
Stomach
 16 1.4 0.8-2.2 1 1.6 0.0-8.6 10 3.2 1.5-5.8 13 2.3 1.2-3.9
Colon
 43 1.5 1.1-2.1 6 2.7 1.0-5.8 15 1.5 0.9-2.5 18 1.2 0.7-1.8
Nonmelanoma
 60 1.1 0.8-1.4 2 0.6 0.1-2.0 25 1.6 1.0-2.3 33 1.3 0.9-1.8
Testis
 5 2.2 0.8-5.1 0  ---  --- 2 2.7 0.0-9.9 1 2.2 0.0-12.4
NOTE. First year of follow-up excluded.
* Not all sites shown.

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