Hepatitis C Virus Dynamics In Vivo: Effect of Ribavirin and Interferon Alfa on Viral Turnover
table 1. Demographic, Biochemical, Serological, and Histological Profile of Patients With Chronic Hepatitis C Treated With 3 × 3 MU rIFN-, 3 × 6 MU rIFN-,, or 3 × 6 MU rIFN-, Per Week Plus Ribavirin (14 mg/kg of body weight per day) |
|
Characteristics |
3 × 3 MU rIFN-= SRC=”b_alpha.gif”> (N = 26) |
3 × 6 MU rIFN-= SRC=”b_alpha.gif”> (N = 19) |
3 × 6 MU rIFN-= SRC=”b_alpha.gif”> + ribavirin (N = 18) |
|
Age (yr) |
44 ± 13 |
43 ± 12 |
40 ± 11 |
Sex (M/F) |
16/10 |
12/7 |
11/7 |
Genotype |
HCV-1 |
17 |
12 |
11 |
HCV-2 |
6 |
2 |
4 |
HCV-3 |
3 |
5 |
3 |
Pretreatment HCV RNA+ |
5.0 × 106 |
3.8 × 106 |
6.5 × 106 |
|
(0.15-100 × 106) |
(0.56-13 × 106) |
(0.24-38 × 106) |
Serology |
Anti-HCV |
26 |
19 |
18 |
HBsAg |
0 |
0 |
0 |
Anti-HBc |
7 |
9 |
6 |
Anti-HIV |
0 |
0 |
0 |
Laboratory data |
ALT (U/L) |
79.3 ± 45.4 |
76.4 ± 47.2 |
53.1 ± 32.8 |
AST (U/L) |
41.3 ± 30.8 |
40.3 ± 20.3 |
31.6 ± 20.7 |
Bilirubin (µmol/L) |
11.3 ± 3.6 |
9.4 ± 7.8 |
10.5 ± 3.7 |
Albumin (g/L) |
44 ± 9 |
49 ± 3 |
50 ± 3 |
-Globulin (g/L) |
16 ± 5 |
15 ± 4 |
16 ± 5 |
Liver histology |
Minimal activity |
4 |
3 |
7 |
Moderate activity |
14 |
6 |
5 |
Severe activity |
5 |
9 |
2 |
Active cirrhosis |
3 |
1 |
4 |
Initial decline of HCV RNA below detection limit(genotype HCV-1, -2, -3) |
10/26 (4, 4, 2) |
10/19 (4, 2, 4) |
10/18 (4, 4, 2) |
|
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Copyright © 1998 by the American Association for the Study of Liver Diseases.