Oral Hep C Trio Cured Over 90 Percent in Phase II Trial
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Abbott Hepatitis C Combo Impressive in Small Study
From U.S. Centers for Disease Control and Prevention
April 6, 2012
A combination of oral hepatitis C drugs being developed by Abbott Laboratories realized cure rates exceeding 90 percent in treatment-naïve patients, according to a small, mid-stage study. The results, released Wednesday, will be presented later this month in Barcelona at a meeting of the European Association for the Study of the Liver.
For 12 weeks, patients in the Phase II trial, known as “Co-Pilot,” received Abbott’s protease inhibitor ABT-450, boosted by the antiviral drug ritonavir with its polymerase inhibitor ABT-333, and ribavirin, which is used in all current hepatitis C regimens. Patients’ blood virus levels were checked 24 weeks later for a sustained virologic response. Those achieving SVR were considered cured.
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21 Comments
Is it just me or do most of the trials and drug company’s test and treat non Geno type 1. Is it because they want the head line 98 % cure. Read a little further and you find out at the bottom of the news release only 47% cure Geno Tape 1…Hell that’s what it is with just interferon and ribavirin,
Hello Newkid , i had Geno typ1 (1.5 melion IU/ml ) last year i finsh the the treatment with interferon and ribavirin at 5th week load become 2000 IU/ml and after 12 th week was negative , i finshed the complet course 48 weeks at end was negative – 6 mounth later i made PCR I found 200000 IU/ml – then i made IL28B rs12979860 genotype i found my type C/T which is not working good with interferon and ribavirin i donot know what to do or why is that is this new durgs protease inhibitor can really help or it is just new bessenies i really need help about this matter adelsobhy555@yahoo.com
I agree that they try to raise expectations by highlighting the Super Good News while hiding the details. I have Genotype 4 (predominant in Egypt) and my experience with the standard regimen of interferon and ribavirin was not good as relapsed after 4 months.
We have no other option that hoping and live with this hope while living and coping the best we can.
God bless all
Hi Andro
I feel your pain.I was diagnosed wth the same and the most horrific part-my medical aid refused to pay for my treatment.On top of this I was also refused treatment through a government hospital who informed me to return to private hospital.I have used approximately R300 000,00 and I still have the virus>The itch is killing me.Never loose hope.I pray daily that researchers also concetrate on genotype 4, which seems at this stage is not the case.
All the best,
Colin
More Hype…… Just another drug company looking for money $.
More Hype, just another drug company trying to get their hands in our pockets.
I agree with you. These doctors are pushing these new miracle cures that really don’t work but sure do make a lot of $$$ for them and the drug companies.
I welcome competition, after all Pagsis is made in Japan and is very over priced.
At least I can’t afford it.
What was the overall mental & physical tolerance of this trio study
It seems to me that most of the testing IS for genotype 1 and NOT for genotype 2, which I have, and am currently waiting for a another go-round of yet the next best treatment, but research takes time, and we may be the guinea pigs. However, don’t lose faith. The cure will happen. Pray. KATRINA
Katrina from what I know you should consider yourself LUCKY! I just met with my GI and he confirmed what I already knew. Genotype 1 & 2 are the easiest to CURE.
Correction – Genotype 2 & 3 are the easiest to CURE. Not 1.
It is strange how they say Geno type 2 & 3 are easiest to cure, yet, I have type 3 and relapsed after 3 months. The other people I know who were “cured” were all Genotype 1. Go figure. I am frustrated because it is difficult to find many tests of drugs and new drugs on Genotype 3! Lots of studies mention type 1.
be cautious of these new treatments. I have been 2 miracle cures that failed in the long run and had to live through a year of hell on each regiment. I will believe it when I see it.
Am looking for any trials, My insurance will only cover partial meds for my Hep-C treatment and would like to get involved somewhere and cut down on the weeks it takes for a cure sincerely Charles T. Purvis
I have Geno type 2 and now found out they want to do a liver biopsy,but I was told that my blood work was good and Liver function also was great so I deceided not to have the biopsy and they are going to keep a check on my numbers, so I pray about.
I i’m currenty on three med’s for my Hep C, Victrelis (Boceprevir) , Pegasys (Peginterferon) ,& Ribasphere (Ribavirin). I believe i ‘m in phase 2, but I don’t remember my Geno type. Had the Liver biopsy done. Now waiting for my Hemotologist to give my shot’s to get my blood count back up. Was wondering if anyone found success with any herbal supplment?. I take Milk thisle daily, but was wondering if there were other good one’s out there i’ll keep ya posted feedback is greatly appreciated thank’s god bless. pray for the cure
God is on your side
Hi Friend-I was in Johannesburg- South Africa for an appointment relating to hep c meds.A wonderful doctor who is involved in liver transplant informed me that the treatment you on works for genotype 1.Unfortunately I am genotype 4 and this strain mainly exist in Egypt and my best bet is to attend trials either in Egypt or Belgium.Please find out what is your genotype.I pray for you it is genotype 1 cause chances of success are greatly improved.I am genotype 4 and the cure at this stage is not available.
Colin
Hi Genotype 4 in the US, told by my Dr that Gilead will be doing a clinical trial involving type 4’s. Lets hope they don’t forget about us.
I wonder about the side affects of the new treatmenT?
I have genotype 3 and was not successful with treatment of Interferon and ribavirin Even though I was told genotype 3 was the easiest to cure. My specialist told me that the reason all the studies for new drugs are with people who have genotype 1 is because of the FDA funding.