Patient Enrollment Started in the Phase II HELIX-2 Clinical Trial
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Idenix Pharma begins Phase II combination trial to treat hepatitis C virus infection
PBR Staff Writer
Published December 3, 2013
US-based biopharmaceutical company Idenix Pharmaceuticals has started patient enrollment in the Phase II HELIX-2 clinical trial evaluating an all-oral, direct-acting antiviral (DAA) HCV combination therapy of samatasvir, simeprevir and TMC647055 for the treatment of hepatitis c virus (HCV) infection.
Samatasvir is a once-daily pan-genotypic NS5A inhibitor of Idenix; simeprevir is a once-daily NS3/4A protease inhibitor jointly developed by Janssen R&D Ireland and Medivir; while TMC647055 is a once-daily NS5B non-nucleoside polymerase inhibitor boosted with low-dose ritonavir developed by Janssen.
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13 Comments
Breaking News???? Olysio is old news. I was hoping it was for Sofosbuvir. Dang!
Oh I’m happy they are working on the epidemic of Hep C. Thank You God. I have had it since 1998, and believe it is causing me to feel tired and other health issues.
HCV symptoms do mimic other diseases like arthritis or fibromyalgia. And I agree these are happy times. I’m holding my breath for Sofosbuvir to be approved Sunday. Then I will still be taking interferon/Ribavirin. But only 12 weeks. I’ve had HCV 41 years & can’t wait until late 2014 or 2015.
Hey, Barbara! If you’re Geno 1, are you going to wait for Sofosbuvir and Ledip combo? That’s the working combo for Geno 1’s with or without RIba and no Interferon.
I’m G1a with compensated cirrhosis. So no waiting. Dr is sending letter of medical necessity to insurance so they will cover it. I’ll be doing Sovaldi/Interferon/Ribavirin for 12 weeks. Sovaldi is Sofosbuvir now approved by FDA as of Friday. I have a great coach who went through 26 weeks and great family support if I need it.
I’ll be praying for you lady! Strike while the iron is hot I guess. Keep me up to date! I’d love to hear how treatment is going and how your results come out! 🙂 Kick some dragon butt!
I certainly will.
How goes it chica? When do you start?
Sorry, been preoccupied. I take my 6th of 12 injections this Friday night. My doctor called me Monday and said the virus is undetected!!!! Side effects are manageable or at least tolerable. I have Benadryl, Phenergan, Hydrocortisone and Goody Powder for aches. Don’t get me wrong there have been some trying times, but its just a moment and it will pass. 😉
Awesome! Way better than Triple Current therapy, that’s for sure! I’m so excited for you! Keep me posted sweet lady, and hope to hear you’re still undetected a few weeks from now!
I have been investing in Benitec, and it has been paying off big! They are coming out with a one shot cure! Clinical trials start in March. If you want to invest in something that will give you some big time returns, check out Benitec! You’re going to feel like a whole new woman 6 months from now! I can’t wait to hear from you then. Stay well!
Hello Brama & AnnT.
Injection #11 this Friday & last #12 next Friday. Then finish out the week with the Ribavirin & Sovaldi AND I’M DONE & DONE!!! The Monday or Tuesday after my last injection I’ll go in for another viral load test. Then again 12 weeks, 6 months and 1 year after treatment.
It was up & down last week (mostly down). I slept a whole lot. Then I noticed I had not been drinking enough water. When I did, I started feeling better–somewhat. REMEMBER THE H2O!!!
I get the flu-like feeling every day, but Goody Powder knocks that out pretty quick. I have Phenergan for nausea, Benadryl for itchiness. When all the side effects attack at once, I take 1/4 of a Suboxone and within 5 minutes I feel soooo much better. Every-thing comes & goes and I have no idea what kicks one side effect in full mode or another. Its no joke and its not very pleasant, but “doable” is about to become “done-able”.
Good luck to everyone out there. If ya can’t wait for the next approvals, DON’T WAIT. Apparently Sovaldi not only lessens the time treatment takes, but also the side effects too, somewhat. GOD BLESS.
BarbaraT
I can’t wait for benitec to start clinical trials. Glad to hear your almost finished! I can tell you’re doing better even by your post! :-). God bless ya lady!
I, too am G1a and compensated cirrhosis…my doc said 24 weeks…how are you? Are you non detectable? How are you feeling?