Triple Therapy with GS-7977 Successful Against Hepatitis C
Share
Follow Us
GS-7977 with interferon/ribavirin cures most treatment-naive hepatitis C patients in 12 weeks
Liz Highleyman
Produced in collaboration with hivandhepatitis.com
Published: 30 April 2012
Adding GS-7977 to pegylated interferon and ribavirin for 12 weeks led to a sustained response rate of 90% for previously untreated chronic hepatitis C patients with difficult-to-treat genotype 1, researchers reported at the 47th International Liver Congress (EASL 2012) last week in Barcelona.
Last year’s approval of the first direct-acting antiviral agents has changed the face of hepatitis C treatment. The first such drugs still must be taken with pegylated interferon and ribavirin, but they increase cure rates and offer the potential for shorter treatment.
Continue reading this entire article:
http://www.aidsmap.com/GS-7977-with-interferonribavirin-cures-most-treatment-naive-hepatitis-C-patients-in-12-weeks/page/2333885/
25 Comments
hi there, is GS-7977 been used for Geno type 4? do you have same sustained virologic response, what clinic running trails for geno type 4
thanks
did you even read the article?
it tells ya…..
I was prescribed ribavirin/interferon for geno type 2, after taking the shot and the pills (for 2 days), I started bleeding at the hair folicles and my right thumb swole up 3 times larger than the left thumb. After the 4th day, I was bleeding from the right thumb nail, then after the 6th day of taking the pills I returned to the prescribing doctor who told me to continue with the meds. I would not take another shot. On the eighth day (after discontinuing the pills & meds on the 6th day) My right thumb nail literally “blew” off of my thumb. It took me 3 weeks to get to get over the 1 week of taking these meds !!
Everybody has different symptoms from the shot & pills.My side effects are minor and I have been on this for 6 months.
I have some great news for the “sheepole”, hep C won’t kill you. Only 2-5% of the people with the infection die from it. If you change your lifestyle (diet, alcohol, etc.) chances are you will die from something else first. The drug companies are using you as a testing ground , as a lab rat !!
Sure wish someone would have told that to my neighbor. He died two years ago. He was only 51 years old. No, the infection may not kill you, but the sclerosis or the liver cancer you get from it will.
So True! My mom passed away at 57 because of the disease. It caused her liver to fail. She became to ill for treatment or any kind of liver transplant.
I belive the same diet and alcohol is a big factor, sometimes i still drink, i take tests once a year and my last test i improved and the doc told me to come back in two years. all this test can make it worse, in joy life
I agree with you Robert. My gastro- said most people do not die from hep c.but from something else first.It’s a hard row to hoe, but trust in God.
Hepatitis C leads to cirrhosis. Cirrhosis leads to liver failure.This also leads to hepatorenal syndrome in many patients. Type I hepatorenal syndrome is fatal 100% of the time within 6 months. Type II also has high mortality rate. Cirrhosis also causes ascites – fluid buidup in abdomen, which if untreated can cause spontaneous bacterial peritinitis. Hepatitis C also leads to HCC (liver cancer) in approx. 20% of patients. If caught early, a liver transplant can rid the body of the cancer. If the cancer should spread, survival is greatly reduced.
Hepatitis C does not kill you – it just causes other ailments that do kill you. Saying it does not is like saying a car that hit a pedestrian did not kill the pedestrian. Yes, the pedestrian died of massive blood loss. This massive blood loss was caused by the car hitting the victim.
you really need to investigate before you go making statements like that! You OBVIOUSLY know NOTHING about what your saying! It is idiots like you that cause people to let their disease go, and DIE from what is known as the Silent Killer!!! Get a real life!
It’s the liver will that kill you and there is no cure for cirrhosis. HCV eats away at it for years then before you know it cirrhosis. Even if you don’t drink like me. I got HCV from the service and after 30 yrs found out about the cirrhosis.
HOW DO I KNOW I NEED TO TAKE THESE WHILE I HAVE ALREADY TAKEN INTERFERON AND RIBAVARIN TWICE BUT MY VIRUS IS STILL POSITIVE?
I did treatment in 2004. I was OK for the first 6 months after , but then the virus came back. I am co-infected with HIV too but I handle it very, very well. 26 years and never been sick. I hope there is a hep C treatment soon that we co-infected can take. I have a strong immune system and would love to take a shorter treatment. that year about did me in because of Anemia. !!!!! LOL
i also did treatment in 2000 with both rib and interferon then rib and peg interferon and levels came back after 6 months and was also anemic with the new stuff they talk about 12 week there is a response what about a year or two my doc wants me to start but im not sure if it is really tested enough
Hi,
I’m on in my 15th week of the 26 to 48 week program.
The program includes Pegesus interferon. One shot a week.
Ribavirin and Incivik. I took 6 pills of the incivik per day for 12
weeks. This is a tough drug for two reason. The side effects and the fact of having to eat 20 grams of fat with the pills. You have to take 2 pills three times a day. Every 8 hrs. You have a 1 hour window between the 8 hour time frame. Remember if you are traveling to another time zone you have to take that into consideration. Side effects are nausia, rash, fatigue, shortness of breath, loss of hair, depression.
On a positive note, 12weeks later you are off of it. Since everyone is already taking the interferon peg. and ribavirin you know what those side effects. I started the rib with 6 pills a day. 3 twice a day. Beceause of what it was doing to my red blood cells. I have been cut down to 1 pill a day and they had to put me on proqurit which is a weekly enjection at the cancer center. Based on results so far. I have about 11 weeks left of treatment. I have been in rimission for the past 8 weeks.
The meds are difficult but matter of life and death it is worth it.
Don’t be afraid of the Incivik and please talk to your Dr. about it. It was approved by the FDA about two yrs. ago.
I hope this helped.
Serge
Sign petition below urging Gilead Sciences to go forward in trials with BMS with the two drugs GS-7977 & daclatasvir, which cured 100% of genotype 1 WITHOUT interferon OR ribavirin…with minimal or NO side effectst!
http://www.change.org/petitions/gilead-sciences-a-phase-iii-collaboration-for-the-treatment-of-hepatitis-c
I am wondering if anyone knows if you have received a liver transplant due to Hep C and still have the virus, is it possible to toterate this treatment?
I found out I was + in Oct.2011. It’s June 2012 and I’ve given up drinking. I believe I got the virus when I was down & out and unemployed. God gave me another chance and I’m working my way back — paying off debt, etc. It feels wonderful to work again and that’s what scares me. I’d like to try the interferon but I can’t risk losing my job. I have great insurance now but I am so scared that my body won’t like it and the potential that I miss so many days of work and there I am, without work. The other part is my parents finding out. I would hurt them so much if they knew and even more so, how i got the virus in the first place. It’s all I think about, day in and day out. I can be having a good day, then it hits me. Thank you for having a website where I can read about experiences of others. My heart goes out to you all.
Hey…we all have made mistakes in our lives (even your parents) so don’t be too hard on yourself. I was diagnosed last Sept…and went into full panic mode. I followed clinical trial with GS 7977 and daclatasvir…the results were 100% in GT1 and 91% for GT3…WITHOUT interferon or ribavirn. Check out the petition at
http://www.change.org/petitions/gilead-sciences-a-phase-iii-collaboration-for-the-treatment-of-hepatitis-c urging Gilead Sciences to go forward with these trials and put “patients before profits”. There are a lot of new drugs on the horizon for GT1 (I am GT3) so hang in there, and keep learning as much as you can about HCV…I wish you the best!
Don’t feel like you can’t tell your parents. Most of us who are parents would want to know so we could help you through it. Not knowing and then finding out later, when it might be too late to help you is worse than knowing now. Parents will always forgive and love you no matter what you have done in the past. Remember they gave birth to you and would want to protect you and help you. I am a parent and thought hiding the fact that I am Hep C positive from my daughter would be best. In the end it hurt her more not knowing what was going on with me. I just found out I was positive in March 2012. My mom passed away because of this disease back in 2001. I know how bad the effects of this disease can be on the body and how import it is to get treatment early. I have made plans with my doctor to start treatment this August when my daughter goes back to school. I am determined to not let it beat me. I am very strong and healthy for a 45 yr old and want to be around a long time to watch my 10 yr old daughter grow up.
I have just found out I have the antibodies and will be getting my liver biopsy results back tomorrow. I have never been a drinker, drug user or sexualy active outside my marriage. I can only accept that during one of my surgeries I was given blood. I found out I was + by donating blood at a recent blood drive and two weeks later I received a letter telling me I had the Hep C Antibodies. I immediately began research,followed up with another blood test with my Dr. and then went to a specialist. They all said-you just don’t fit the profile of having this disease. My husband gave blood the same day I did and he’s not positive (thank goodness) and I just pray that my children won’t be either. I am very hopeful and with God’s help I will remain faithful that with the new medications I can get rid of this disease. I ask for your prayers and will be praying for everyone fighting to beat this. I pray that each one of us have the strength to get through each day. I am very blessed to be surrounded by family and people who will support me once I get started with whatever treatment I will be given.
I found out april 2012 that I am possitive. I took a flight for life for liver failure and drug overdose because the pain meds that im on wouldnt prosess because of the liver. here it is 3 months later and the doctor told me today that i have cirrhosis and my liver is leaking out into my stomach. ive gained almost 30 pounds this last month, and I only eat one small meal a day. never hungry. Im only 34 years old. Im scarred to death. I have no insurance and no way to pay for the meds. This sucks
I was on the first 12 study of 7977. With SOC and now 3 years later I am still free of that horrible disease. I was scared to do a clinical and an early one at that,,,,,,, but I was more afraid of not getting treated in time…
Thank you Pharmasett and Gilead!
12 week study..D’oh