Vertex Pharmaceutical’s New Hepatitis C Drug May Have Negative Effects
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The Editors at Hepatitis Central
July 29, 2013
In a study for the drug VX-135, patients developed increased levels of liver enzymes. The FDA has put a partial clinical hold on the drug until they can fully study their toxicity concerns.
Vertex: FDA Puts Partial Hold on Study of Hepatitis C Drug
By Kristin Jones
Vertex Pharmaceuticals Inc. (VRTX) said the U.S. Food and Drug Administration has put a partial clinical hold on a mid-stage study of its experimental hepatitis C treatment VX-135 because of toxicity concerns.
Vertex shares fell 9.1% to $79.66 in after-hours trading.
The drug developer said the hold affects the 200-milligram dose of VX-135, a drug known as a nucleotide polymerase inhibitor, or “nuke,” which is designed to combat hepatitis C infection inside liver cells. Vertex joins Bristol-Myers Squibb Co. (BMY) and Idenix Pharmaceuticals Inc. (IDIX) in having to halt certain trials of nuke drugs because of toxicity concerns.
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