Vosevi (sofosbuvir, velpatasvir and voxilaprevir)
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When is Vosevi contraindicated?
Vosevi is contraindicated for use with rifampin.
The following chart provides information regarding additional medications that can have potential interactions with Vosevi. This table is not all inclusive.
| Drug Class | Specific Drugs Within Class Contraindicated with Vosevi |
|---|---|
| Acid Reducint Agents | Antacids, H2-receptor antagonists, Proton-pump inhibitors |
| Antiarrhythmics | Amiodarone, Digoxin, |
| Anticoagulants | Dabigatran Etexilate |
| Anticonvulsants | Carbamazepine, Phenytoin, Phenobarbital, Oxcarbazepine |
| Antimycobacterials | Rifampin, Rifabutin, Rifapentine |
| Antiretrovirals | Atazanavir, Lopinavir, Tipranavir/Ritonavir, Efavirenz, Tenofovir Disoproxil Fumarate |
| Herbal Supplements | St. Johns’ wort (Hypericum perforatum) |
| HMG-CoA Reductase Inhibitors | Pravastatin, Rosuvastatin, Pitavastatin, Atorvastatin, Fluvastatin, Lovastatin, Simvastatin |
| Immunosupporessants | Cyclosporine |
Last Updated: October 2017
"FDA approves Vosevi for Hepatitis C" FDA.gov. U.S. Food & Drug Administration. https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm567467.htm. Retrieved October 6, 2017.
"Highlights of Prescribing Information." Gilead.com. Gilead Sciences Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/vosevi/vosevi_pi.pdf. Retrieved October 6, 2017.
"Vosevi is FDA approved." Vosevi.com. Gilead Sciences Inc., http://www.vosevi.com/. Retrieved October 6, 2017.
